Colon cancer cells produce immunoregulatory glucocorticoids
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منابع مشابه
Drug-resistant colon cancer cells produce high carcinoembryonic antigen and might not be cancer-initiating cells
PURPOSE We evaluated the higher levels of carcinoembryonic antigen (CEA) secreted by the LoVo human colon carcinoma cells in a medium containing anticancer drugs. Drug-resistant LoVo cells were analyzed by subcutaneously xenotransplanting them into mice. The aim of this study was to evaluate whether the drug-resistant cells isolated in this study were cancer-initiating cells, known also as canc...
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متن کاملBombesin and glucocorticoids stimulate human breast cancer cells to produce endothelin, a paracrine mitogen for breast stromal cells.
Human breast cancer cells have been recently reported to produce endothelin (ET) 1. To investigate the potential regulation of ET production in breast cancer cells, we have measured the release of ET-like immunoreactivity from the T47D cell line in response to various paracrine/endocrine factors. Bombesin (0.1 microM) and cortisol (1 microM) stimulated maximal respective increases in IR-ET rele...
متن کاملColon cancer stem cells.
This unit describes protocols for working with colon cancer stem cells. To work with these cells one must start by generating single-cell suspensions from human colon cancer tissue. These cell suspensions are sorted using flow cytometry-assisted cell sorting to fractionate the cells into tumor-initiating and nontumor-initiating subsets. Once the cells have been fractionated, they must be functi...
متن کاملBombesin and Glucocorticoids Stimulate Human Breast Cancer Cells to Produce Endothelin, a Paracrine Mitogen for Breast Stromal Cells1
Human breast cancer cells have been recently reported to produce endothelin (ET) 1. To investigate the potential regulation of ET produc tion in breast cancer cells, we have measured the release of ET-like immunoreactivity from the T47D cell line in response to various paracrine/endocrine factors. Bombesin (0.1 ¿IM) and Cortisol (l /IM)stimulated maximal respective increases in IR-ET release t...
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ژورنال
عنوان ژورنال: OncoImmunology
سال: 2012
ISSN: 2162-402X
DOI: 10.4161/onci.19459